Download E-books Progress in Polyamine Research: Novel Biochemical, Pharmacological, and Clinical Aspects PDF

By Olli A. Jänne, Anne Crozat, Mervi Julkunen, Noreen J. Hickok, Leonard Eisenberg (auth.), Vincenzo Zappia, Anthony E. Pegg (eds.)

This e-book includes the medical contributions provided at a global Symposium held in Sorrento, Italy, in June 1988 below the auspices of the collage of Naples, the Italian Society of Biochemistry, and the nationwide examine Council. the trendy heritage of polyamines dates again to 1958 while the Tabors and Rosenthal first defined the outlines in their organic synthesis. From then on, and especially within the final ten years, a veri desk explosion of Literature, characterised by means of hundreds of thousands of papers, has witnessed the curiosity of the clinical group towards those molecules. probably the outdated assertion that "polyamines are molecules looking for a functionality" isn't any longer precise this present day. plenty of results exerted by means of those uncomplicated molecules are renowned, and in lots of instances the mechanisms underlying those results were elucidated. the 1st portion of the amount is fullyyt dedicated to the enzymology and molecular biology of ornithine decarboxylase. in view that its discovery by means of Gale greater than 40 years in the past, this is often thought of one of the most generally studied enzymes in biology, and the most complicated types in enzyme rules. The mechanism of regulate of the enzyme task on the transcriptional, post-transcriptional and post-translational degrees, in addition to the effective rules by means of antizyme, are mentioned intimately. the second one staff of contributions bargains wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the opposite enzymes regarding polyamine interconversion and regeneration.

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